”Länsikauppakin meille sentään jotakin merkitsee” : Johan Nykopp Suomen Washingtonin -lähettiläänä 1951– 1958

Tutkielmani aiheena on Johan Nykoppin toiminta Suomen Washingtonin -lähettiläänä vuosina 1951–1958. Tutkimuskirjallisuudessa Nykoppia on kuvailtu länsimieliseksi lähettilääksi, joka pyrki työssään vahvistamaan Suomen läntisiä talousyhteyksiä harvinaisen aktiivisesti. Pelkästään häntä koskevaa tutkimusta ei kuitenkaan aiemmin ole tehty. Työssäni selvitän, miten Nykopp käytännössä edisti tavoitettaan Suomen viennin kasvattamisesta ja sen suuntaamisesta länteen. Lisäksi tarkastelen, miten hän kuvasi raporteissaan Suomen ja Yhdysvaltain suhteita ja millaista politiikkaa hän suositteli niissä kotimaan päättäjille. Lähteinä käytän pääasiassa Nykoppin diplomaattiraportteja sekä kirjeenvaihtoa lähettiläskauden ajalta. Niiden antamaa kuvaa täydennän tutkimus- ja muistelmakirjallisuuden avulla. Osoitan tutkielmassani, että Nykoppilla oli lähettiläskautensa aikana merkittävä panos Suomen ja Yhdysvaltain suhteiden kehittämisessä. Tutkimustulokseni vahvistavat tulkintaa, jonka mukaan Nykoppin toimintaa Suomen ulkomaankaupan laajentamiseksi ja integroimiseksi läntisille markkinoille on pidettävä poikkeuksellisen oma-aloitteisena ja ahkerana. Hänen toimintansa voi myös nähdä vastapainona ajanjakson yleiselle kehitystrendille, Suomen idänkaupan voimakkaalle kasvulle. Tutkielma täydentää siten kuvaa Suomen ulko- ja kauppapolitiikasta kylmän sodan alkuvuosina sekä Suomen ja Yhdysvaltain suhteiden kehityksestä 1950-luvulla.Siirretty Doriast

Down-regulation of progesterone receptor membrane component 1 (PGRMC1) in peripheral nucleated blood cells associated with premature ovarian failure (POF) and polycystic ovary syndrome (PCOS)

<p>Abstract</p> <p>Background</p> <p>Progesterone receptor membrane component 1 (PGRMC1) is a member of a progesterone-binding complex implicated in female reproduction. We aimed i) to determine the natural expression of PGRMC1 in peripheral nucleated blood cells throughout the menstrual cycle and ii) to investigate any association between PGRMC1 levels in leukocytes and conditions characterized by reduced fertility.</p> <p>Methods</p> <p>We analyzed PGRMC1 expression in peripheral leukocytes from 15 healthy cycling women over four weeks. Additionally, we determined PGRMC1 levels in samples from patients with premature ovarian failure (POF) and polycystic ovary syndrome (PCOS) as well as in healthy postmenopausal women and male controls. The levels of PGRMC1 protein in nucleated peripheral blood cells were quantified by Western blot analysis.</p> <p>Results</p> <p>PGRMC1 levels did not vary significantly throughout the menstrual cycle. We observed a significant down-regulation of PGRMC1 in postmenopausal women and in patients with premature ovarian failure (POF) and polycystic ovary syndrome (PCOS) when compared to early follicular phase of healthy women.</p> <p>Conclusion</p> <p>This study suggests that reduced levels of PGRMC1 in peripheral leukocytes are associated with perturbed ovulatory function.</p

Ribosomal protein S19 and S24 insufficiency cause distinct cell cycle defects in Diamond–Blackfan anemia

AbstractDiamond–Blackfan anemia (DBA) is a severe congenital anemia characterized by a specific decrease of erythroid precursors. The disease is also associated with growth retardation, congenital malformations, a predisposition for malignant disease and heterozygous mutations in either of the ribosomal protein (RP) genes RPS7, RPS17, RPS19, RPS24, RPL5, RPL11 and RPL35a. We show herein that primary fibroblasts from DBA patients with truncating mutations in RPS19 or in RPS24 have a marked reduction in proliferative capacity. Mutant fibroblasts are associated with extended cell cycles and normal levels of p53 when compared to w.t. cells. RPS19 mutant fibroblasts accumulate in the G1 phase, whereas the RPS24 mutant cells show an altered progression in the S phase resulting in reduced levels in the G2/M phase. RPS19 deficient cells exhibit reduced levels of Cyclin-E, CDK2 and retinoblastoma (Rb) protein supporting a cell cycle arrest in the G1 phase. In contrast, RPS24 deficient cells show increased levels of the cell cycle inhibitor p21 and a seemingly opposing increase in Cyclin-E, CDK4 and CDK6. In combination, our results show that RPS19 and RPS24 insufficient fibroblasts have an impaired growth caused by distinct blockages in the cell cycle. We suggest this proliferative constraint to be an important contributing mechanism for the complex extra-hematological features observed in DBA

Eurooppalaisen innovaatiopolitiikan uusi vaihde vihreässä siirtymässä jatkaa monitasoisen hallinnon tiellä

Uuden vihreän innovaatiopolitiikan alustaksi muodostuvat alueelliset yhteistyöverkostot älykkään erikoistumisen strategioiden toteuttamisessa. Euroopan komission ja Alueiden komitean aloitteella Partnerships for Regional Innovation Pohjanmaalla haetaan seuraavan vaiheen vihreän siirtymän innovaatiopolitiikkaa

Targeted Resequencing and Analysis of the Diamond-Blackfan Anemia Disease Locus RPS19

BACKGROUND: The Ribosomal protein S19 gene locus (RPS19) has been linked to two kinds of red cell aplasia, Diamond-Blackfan Anemia (DBA) and Transient Erythroblastopenia in Childhood (TEC). Mutations in RPS19 coding sequences have been found in 25% of DBA patients, but not in TEC patients. It has been suggested that non-coding RPS19 sequence variants contribute to the considerable clinical variability in red cell aplasia. We therefore aimed at identifying non-coding variations associated with DBA or TEC phenotypes. METHODOLOGY/PRINCIPAL FINDINGS: We targeted a region of 19'980 bp encompassing the RPS19 gene in a cohort of 89 DBA and TEC patients for resequencing. We provide here a catalog of the considerable, previously unrecognized degree of variation in this region. We identified 73 variations (65 SNPs, 8 indels) that all are located outside of the RPS19 open reading frame, and of which 67.1% are classified as novel. We hypothesize that specific alleles in non-coding regions of RPS19 could alter the binding of regulatory proteins or transcription factors. Therefore, we carried out an extensive analysis to identify transcription factor binding sites (TFBS). A series of putative interaction sites coincide with detected variants. Sixteen of the corresponding transcription factors are of particular interest, as they are housekeeping genes or show a direct link to hematopoiesis, tumorigenesis or leukemia (e.g. GATA-1/2, PU.1, MZF-1). CONCLUSIONS: Specific alleles at predicted TFBSs may alter the expression of RPS19, modify an important interaction between transcription factors with overlapping TFBS or remove an important stimulus for hematopoiesis. We suggest that the detected interactions are of importance for hematopoiesis and could provide new insights into individual response to treatment

SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts

Acknowledgements We sincerely thank the patients and family members who participated in this study. We would also like to thank Stefan Esher, Umeå University, for help with genealogy, and Anna Westerlund for excellent technical assistance. This work was supported by grants from the FOU, at the Umeå university hospital, and the Medical Faculty at Umeå University. The work at University of Gothenburg was supported by grants from The Swedish Research Council, the Swedish Rheumatism Association, the Royal 80-Year Fund of King Gustav V, ALF/LUA research grant from Sahlgrenska University Hospital in Gothenburg and the Lundberg Foundation. The work at the University of Gothenburg and the University of Aberdeen was supported by Euroclast, a Marie Curie FP7-People-2013-ITN: # 607446.Peer reviewedPublisher PD

3D-Structure ofNEGIS shearmarginsfromradarstratigraphy

The North East Greenland Ice Stream (NEGIS) is delineated by well-defined shear margins, which are evident in the gradient of surface velocity field as well as in the surface topography, where they form troughs up to ten meters deep. In the upper part of the ice stream the margins appear not to be linked to bedrock topography. To understand this efficient system of mass transport towards the ocean it is essential to investigate the nature of the shear margins, as here very localized deformation decouples the inner ice stream from the slower flowing surrounding ice sheet. This process is influenced by several factors and feedback mechanisms, including the crystal fabric orientation, strain heating and localization of meltwater. In summary, the shear margins are area-wise a small part of the ice stream itself, but the processes leading to the localization of deformation are of similar importance for ice discharge as the processes enabling fast flow of the main trunk over the bed. We present results from an airborne radar survey with the AWI Ultra-Wide Band Radar system, covering an area 150 km upstream and 100 km downstream of the deep drilling site on the ice stream (EGRIP). Over the survey area the ice stream accelerates from 12 m/a to 75 m/a. We focus on the signatures of the shear margins in the radar data. In the regions of localized shear, the internal reflections in the radargrams show disturbances in the form of steep undulations, or chevron folds, which are intensified with ongoing shear. As the ice stream has been covered with 36 flow-perpendicular radar sections we are able to show the evolution of these characteristic signatures over the survey area, and thus, as an analog, over time. 3D-representations of the folded stratigraphic layers reveal how new folds are formed when the ice stream widens and how older structures are preserved in the outer part of the main trunk, where they are no longer subject to shear. Furthermore, we link the change of the shape of the internal reflections in the shear zones to a strain rate field calculated from high resolution flow velocities derived by TerraSAR-X data

Ice-flow history and observations from the ice base of Jutulstraumen drainage basin (Antarctica)

Future sea-level predictions require that the history of the Antarctic Ice Sheet is well understood and constrained by observations. Much of the ice sheets’ ice-dynamic properties are governed by processes at the ice-bed interface which can be imaged with radar sounding surveys. Here we use a combination of ultra-wideband radio-echo sounding data, satellite radar and laser altimetry data, as well as electromagnetic waveform modeling to characterize the properties of the ice base and the evolution of the subglacial morphology of the Jutulstraumen drainage basin (western Dronning Maud Land, Antarctica). Based on the classification of the bed topography, we reconstruct the step-by-step modifications the subglacial landscape has experienced since the beginning of the glaciation of Antarctica, 34 million years ago. Between 2017 and 2020, we find evidence of active episodic cascade-like subglacial water transport along the subglacial valley network. In addition, our high-resolution radio-echo sounding data reveal a cluster of anomalous basal ice units whose material properties we constrain by electromagnetic waveform modeling. Through this, we aim to derive the physical conditions at the ice base, and establish a link to the subglacial hydrology system. The combination of these observations will represent an important step towards a better understanding of large-scale ice-sheet dynamics in western Dronning Maud Land